A Plant Defense Metabolite Specifically Suppresses Virulence of Pathogenic Bacteria

  • CAS
  • Published: 2020-04-10
  • 158
When attacked by pathogenic microbes, plants protect themselves by deploying numerous secondary metabolites inhibitory to the pathogen. These metabolites are thought to nonspecifically inhibit both pathogenic and beneficial microbes, which is not desirable to plants.
A research team led by Prof. ZHOU Jianmin from the Institute of Genetics and Development Biology of the Chinese Academy of Sciences and LEI Xiaoguang at Peking University discovered a new mechanism by which a plant defense compound targets pathogenic bacteria without having deleterious effect on commensal bacteria.
Many Gram-negative pathogenic bacteria, such as Pseudomonas syringae, secretes virulence proteins into plant cells through a specialized protein secretion system, a process essential for pathogenicity.
In this study, the researchers identified sulforaphane, a natural product produced by cruciferous plants, covalently attaches to a specific residue of a bacterial protein that is needed to express genes encoding the secretion system. As such the metabolite specifically decreases virulence of the pathogenic bacteria and protects plants. This metabolite does not affect commensal bacteria, as the target protein only exists in the pathogen.
This study demonstrated that plants do possess "smart" chemical that attacks enemy without harming friends, which has not been discovered before.
The work has been published online in Cell Host & Microbe on April 8, 2020.
The work was supported by National Natural Science Foundation of China, the State Key Laboratory of Plant Genomics and the Joint Scientific Thematic Research Programme Grant. 

Figure1. Model for the SFN-mediated repression of virulence gene expression in the bacterial pathogen. (Image by IGDB)
Source: Chinese Academy of Sciences